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Reproducible Cost-Effectiveness Models

Can we trust health economic evaluations of new pharmaceuticals? Examining the impact of the researcher's degrees of freedom using a many-analysts approach

Period 2024-2027
Funding Forte

Project Overview

Given the large economic and public health consequences of drug reimbursement decisions based on cost-effectiveness evidence, it is essential that the cost-effectiveness evidence provides valid input to decision-makers. Our long-term goal is to develop a framework and guidelines for improving reproducibility and reducing the impact of researcher degrees of freedom in pharmacoeconomic models.

Research Aims

The primary aims of the project are:

  1. Reproducibility Assessment: To determine to what degree published pharmacoeconomic models of new cancer drugs are reproducible.
  2. Researcher Degrees of Freedom Analysis: To investigate the impact of researchers' degrees of freedom in the pharmacoeconomic modeling of two novel cancer drugs.

Research Team

Presentations & Publications